Blar i forfatter "Ferrand, Rashida A."

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    • Carotid intima media thickness in older childrenand adolescents with HIV taking antiretroviraltherapy 

      Majonga, Edith D.; Chiesa, Scott T.; McHough, Grace; Mujuru, Hilda; Nathoo, Kusum; Odland, Jon Øyvind; Kaski, Juan Pablo; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04)
      Increased carotid intima-media thickness (cIMT) is reported in both adults and children with human immunodeficiency virus (HIV) in high income settings and is associated with an increased risk of cardiovascular disease, but data from sub-Saharan Africa is lacking.<p> <p>We assessed cIMT using ultrasound in perinatally HIV-infected children aged 6 to 16 years taking antiretroviral therapy (ART) ...

    • Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe 

      Flygel, Trym Thune; Sovershaeva, Evgeniya; Classen-Weitz, Shantelle; Hjerde, Erik; Mwaikono, Kilaza S.; Odland, Jon Øyvind; Ferrand, Rashida A.; McHugh, Grace; Gutteberg, Tore Jarl; Nicol, Mark P.; Cavanagh, Jorunn Pauline; Flægstad, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)
      <p><i>Background - </i>Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4<sup>+</sup> T cells in the gut. Antiretroviral therapy (ART) restores CD4<sup>+</sup> counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV-infected children. We ...

    • Cytomegalovirus-SpecificImmunoglobulin G is associated with chronic lung disease in children and adolescents from sub-Saharan Africa with perinatal HIV infection 

      Bowen, Dan Hameiri; Sovershaeva, Evgeniya; Charlton, Bethany; Schive, Cecilie; Odland, Jon Øyvind; McHugh, Grace; Bandason, Tsitsi; Mayin, Justin; Ferrand, Rashida A.; Yindom, Louis-Marie; Rowland-Jones, Sara L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-26)
      In a cross-sectional study of 296 children and adolescents from Zimbabwe living with perinatal human immunodeficiency virus, individuals with the top tertile of cytomegalovirus-specific immunoglobulin G titer had an increased odds of chronic lung disease (odds ratio, 3.33; 95% confidence interval, 1.37–8.85; P = .010).

    • Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa 

      Majonga, Edith D.; Rehman, Andrea M.; McHugh, Grace; Mujuru, Hilda A.; Nathoo, Kusum; Patel, Mohammad S.; Munyati, Shungu; Odland, Jon Øyvind; Kranzer, Katharina; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-30)
      Background: Echocardiographic reference ranges are important to identify abnormalities of cardiac dimensions. Reference ranges for children in sub-Saharan Africa have not been established. The aim of this study was to establish echocardiographic z-score references for Black children in sub-Saharan Africa.<p> <p>Methods: 282 healthy subjects aged 6–16 years (143 [51%] males) with no known history ...

    • The effect of azithromycin for management of HIV-associated chronic lung disease on right heart function: Results from the BREATHE trial 

      Majonga, Edith D.; Mapurisa, Gugulethu Newton; Rehman, Andrea M.; McHugh, Grace; Bandason, Tsitsi; Mujuru, Hilda; Gonzalez-Martinez, Carmen; Odland, Jon O.; Kennedy, Neil; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-20)
      Background - Right heart abnormalities and pulmonary hypertension (PH) may be secondary to chronic lung disease. Chronic lung disease is common in children with HIV. In the BREATHE trial (Trial registration: NCT02426112), azithromycin (AZM) reduced the risk of acute respiratory exacerbations in children aged 6–19 years with HIV-associated chronic lung disease (HCLD) taking antiretroviral therapy. ...

    • Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial 

      Ferrand, Rashida A.; McHugh, Grace; Rehman, Andrea M.; Mujuru, Hilda A.; Simms, Victoria; Majonga, Edith D.; Nicol, Mark P.; Flægstad, Trond; Gutteberg, Tore Jarl; Gonzalez-Martinez, carmen; Corbett, Elizabeth L.; Rowland-Jones, Sarah; Kranzer, Katharina; Weiss, Helen Anne; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-17)
      <i>Importance</i> - HIV-associated chronic lung disease (HCLD) in children is associated with small airways disease, is common despite antiretroviral therapy (ART), and is associated with substantial morbidity. Azithromycin has antibiotic and immunomodulatory activity and may be effective in treating HCLD through reducing respiratory tract infections and inflammation.<p> <p><i>Objective</i> - ...

    • High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy 

      Majonga, Edith D.; Rehman, Andrea M.; Simms, Victoria; McHugh, Grace; Mujuru, Hilda A.; Nathoo, Kusum; Odland, Jon Øyvind; Patel, Mohammad S.; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-28)
      Background: Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established ...

    • History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children 

      Sovershaeva, Evgeniya; Kranzer, Katharina; McHugh, Grace; Bandason, Tsitsi; Majonga, Edith D.; Usmani, Omar S.; Rowland-Jones, Sarah; Gutteberg, Tore Jarl; Flægstad, Trond; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-01)
      <p><i>Objective - </i>HIV disrupts host defense mechanisms and maintains chronic inflammation in the lung. Nitric oxide is a marker of lung inflammation and can be measured in the exhaled air. We investigated the relationship between exhaled nitric oxide (eNO), HIV status and airway abnormalities in perinatally HIV-infected children aged 6–19 years. <p><i>Design - </i>A cross-sectional study. <p ...

    • The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease 

      Abotsi, Regina E.; Nicol, Mark P.; McHugh, Grace; Simms, Victoria; Rehman, Andrea M.; Barthus, Charmaine; Ngwira, Lucky G.; Kwambana-Adams, Brenda; Heyderman, Robert S.; Odland, Jon Øyvind; Ferrand, Rashida A.; Dube, Felix S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Nasopharyngeal (NP) swabs and sputa were ...

    • Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe 

      Sovershaeva, Evgeniya; Shamu, Tinei; Wilsgaard, Tom; Bandason, Tsitsi; Flægstad, Trond; Katzenstein, David; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-31)
      <i>Objective</i>: To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe.<p> <p><i>Methods</i>: Children (0–19 years) and adults (>19 years) starting ART between 2013 and 2015 were followed for a median of 2.8 and 2.7 years, respectively. The incidence rates of virological failure (VF), low-level viraemia (LLV), and viral ...

    • Prevalence and antimicrobial resistance profiles of respiratory microbial flora in African children with HIV-associated chronic lung disease 

      Abotsi, Regina E.; Nicol, Mark P.; McHugh, Grace; Simms, Victoria; Rehman, Andrea M.; Barthus, Charmaine; Mbhele, Slindile; Moyo, Brewster Wisdom; Ngwira, Lucky Gift; Mujuru, Hilda A.; Makamure, Beauty; Mayini, Justin; Odland, Jon Øyvind; Ferrand, Rashida A.; Dube, Felix S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      <b>Background</b> HIV-associated chronic lung disease (CLD) is common among children living with HIV (CLWH) in sub-Saharan Africa, including those on antiretroviral therapy (ART). However, the pathogenesis of CLD and its possible association with microbial determinants remain poorly understood. We investigated the prevalence, and antibiotic susceptibility of <i>Streptococcus pneumoniae </i>(SP), ...

    • Racial Variation in Echocardiographic Reference Ranges for Left Chamber Dimensions in Children and Adolescents: A Systematic Review 

      Majonga, Edith D.; Norrish, Gabrielle; Rehman, Andrea M.; Kranzer, Katharina; Mujuru, Hilda A.; Nathoo, Kusum; Odland, Jon Øyvind; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-04)
      Abstract Echocardiography plays a critical role in the assessment of cardiac disease. Important differences in echocardiographically derived cardiac chamber dimensions have been previously highlighted in different population groups in adult studies, but this has not been systematically studied in children, whose body size changes throughout childhood. The aim of this study was to review the ...

    • Sputum bacterial load and bacterial composition correlate with lung function and are altered by long-term azithromycin treatment in children with HIV-associated chronic lung disease 

      Abotsi, Regina E.; Dube, Felix S.; Rehman, Andrea M.; Claassen-Weitz, Shantelle; Xia, Yao; Simms, Victoria; Mwaikono, Kilaza S.; Gardner-Lubbe, Sugnet; McHugh, Grace; Ngwira, Lucky G.; Kwambana-Adams, Brenda; Heyderman, Robert S.; Odland, Jon Øyvind; Ferrand, Rashida A.; Nicol, Mark P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)
      Background - Long-term azithromycin (AZM) treatment reduces the frequency of acute respiratory exacerbation in children and adolescents with HIV-associated chronic lung disease (HCLD). However, the impact of this treatment on the respiratory bacteriome is unknown.<p> <p>Method - African children with HCLD (defined as forced expiratory volume in 1 s z-score (FEV1z) less than − 1.0 with no ...